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pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may possibly boost the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will minimize the level or influence of clozapine by influencing hepatic/intestinal enzyme CYP3A